- Researchers report that a new vaccine could one day help prevent the recurrence of colorectal and pancreatic cancer in some individuals.
- The vaccine is still in early development, but the researchers said it appeared safe and effective in a small study.
- Colorectal and pancreatic cancer are two of the most deadly and difficult to treat forms of cancer.
Researchers are reporting that a new vaccine could help prevent the reemergence of colorectal and pancreatic cancer in high-risk people who have previously undergone cancer treatment.
The
Elicio Therapeutics, the makers of ELI-002, funded the study.
Although the drug is still early in development, researchers in charge of the trial say the results are promising.
Colorectal and pancreatic cancer are two of the most deadly forms of cancer. They are the second and third, respectively, leading cause of cancer deaths in the United States, behind only lung cancer. Combined,
The new vaccine works by targeting two genetic mutations of KRAS genes, specifically KRAS G12D and KRAS G12R.
KRAS genes help to regulate cell division and growth. They aren’t inherently harmful, but when they are mutated can become cancerous.
KRAS mutations are found in up to one-in-four cases of all forms of cancer, but in colon cancer that number jumps to
Additionally, KRAS mutations are also associated with lower rates of survival and more aggressive tumor growth.
The goal of the new vaccine is to prevent the cancer from returning after it has been successfully cleared through traditional treatment. It does…
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