- Researchers report in a new study that obesity disrupted the biological metabolic process in mice.
- They noted that this disruption can cause a number of health issues, including liver damage.
- They say they hope their study will help the medical community better understand how obesity and metabolism are linked.
Researchers say they have found that the biological regulation of metabolic activity was reversed in mice with obesity in a
In non-obese mice, the researchers report that allosteric regulation, the biological process that controls metabolism, was inhibited during feeding and activated when the mice were fasting.
In the mice with obesity, researchers said this process was reversed. It was increased during feeding and was inhibited during fasting.
The scientists say they hope that by better understanding how this metabolic process is affected, health professionals can understand how obesity affects the body and contributes to disease development.
In their study, researchers looked at the livers of mice that were at typical weight and compared them to the livers of mice with obesity after periods of both feeding and fasting. They gathered data on different biological processes from five sets of mice. Then, they combined their data with information from biological databases to understand how different layers of processes interact.
Although the researchers looked at how the livers of mice were affected, they said they expected that similar results would occur in humans.
The researchers noted that when we eat, our liver builds up stores of energy and then releases this energy as needed, a process called
In their study, the scientists from the University of Tokyo reported that in mice with obesity, this process became dysregulated, indicating a potential breakdown of the process.
They said this breakdown could lead to metabolic symptoms such as fatigue, lethargy, and decreased appetite.
“Obesity can make…
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