- A new study investigates gene expression in the skin tissue of people with psoriasis.
- The researchers used a relatively new technique called spatial transcriptomics.
- This approach helps map differences in gene expression in healthy and affected skin.
- The researchers said they identified immune cell changes between healthy and diseased skin.
Psoriasis is one of the most common immune-mediated inflammatory diseases, affecting up to 3% of people worldwide.
Aside from its familiar dermatological symptoms, psoriasis also affects other organs and systems.
People with the condition have an increased risk of
In addition, about 1 in 3 people with psoriasis develop psoriatic arthritis.
While scientists have made headway in understanding and treating psoriasis, it is not yet clear why there are variations in symptoms between individuals.
Some people with psoriasis have plaques on just a small part of the body while others experience them over much larger sections of skin. Also, these plaques can vary substantially in thickness, scaliness, and redness.
Evidence shows that the risk of developing
Therefore, it is vital to explore the mechanisms involved in symptom severity and how localized skin inflammation leads to systemic disease.
A recent
“Our initial goal was to find measurable molecular signals that could tell us who is more likely to develop severe psoriasis as well as who is at higher risk of developing related disorders that often accompany psoriasis, such as arthritis and cardiovascular disease,” Dr. Jose Scher, a study co-senior investigator and a specialist in psoriatic disease at NYU Langone Health in New York, said in a press statement.
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