- New research from Mass General Brigham challenges the notion that genetics is the sole determinant in Alzheimer’s risk, particularly for those predisposed to early-onset forms of the disease.
- The study analyzed data from 675 people carrying the PSEN1 E280A genetic mutation, which often leads to Alzheimer’s symptoms appearing around the age of 49 years.
- While those with an additional high-risk mutation experienced faster cognitive decline, the researchers found that higher educational attainment could act as a protective factor, slowing down cognitive impairment even in the presence of strong genetic risks.
In a new study, published in
Scientists examined the role of genetics and educational level in cognitive deterioration by analyzing data from 675 individuals with a genetic mutation known as PSEN1 E280A, which makes them susceptible to early-onset Alzheimer’s disease.
Those with this mutation typically begin showing dementia symptoms around the age of 49.
The researchers discovered that individuals with this mutation who also had a second risk-increasing mutation — APOE e4 — experienced a faster onset of cognitive decline.
Conversely, those with a protective APOE e2 mutation saw a delayed onset of cognitive symptoms.
The study team also evaluated how educational level influenced cognitive abilities in individuals carrying the PSEN1 E280A mutation, including those with various APOE genetic variants.
Their findings suggested that greater educational achievement, or more years of schooling, was linked to better cognitive…
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