- New research highlights the potential of anti-inflammatory drugs, specifically p38 inhibitors, as a treatment for Alzheimer’s disease.
- Scientists at the University of Kentucky’s Sanders-Brown Center on Aging focused on the protein p38, which is being studied by various labs for its role in neuroinflammatory dysfunction.
- By genetically suppressing p38 production in microglia, immune cells in the brain, the researchers observed a decrease in the number of microglia near amyloid plaques, a hallmark of Alzheimer’s.
- These findings suggest that early inhibition of p38 could impact the interaction between brain immune cells and Alzheimer’s disease pathology.
To understand how blocking the production of p38 protein could help with Alzheimer’s disease, the researchers conducted tests on an early-stage mouse model of Alzheimer’s disease.
In this new study, published in
The researchers wanted to see if this intervention could change the way amyloid plaques, which are a key feature of Alzheimer’s, develop in the brain.
The
Scientists are studying this protein as a potential target for developing drugs to treat Alzheimer’s disease and other conditions where there are problems with inflammation in the brain.
In
The drugs that inhibit p38-alpha might be helpful because they can regulate the way certain brain cells called microglia respond to…
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