- Measurements of metabolic health can be used to evaluate the risk of developing cardiovascular disease.
- Researchers in China have also shown that metabolic health can be characterized by the presence and abundance of certain microbes in the gut microbiome.
- Age is also associated with certain characteristics of the microbiome and people with microbiomes associated with younger metrics were less likely to experience cardiovascular disease.
- These findings were verified across Chinese, European and American cohorts.
Scientists have characterized the way age and metabolism can present in the microbiome.
Researchers in China developed an age-related and metabolism-related microbial signature based on findings from investigations in a cohort of over 10,000 Chinese people, and verified it on a cohort of over 9,000 Chinese people.
They then looked at the impacts these signatures had on cardiovascular disease risk.
The researchers published their results in
The gut microbiome is the population of bacteria, viruses and other microbes, playing a role in digestion, but also in other processes, including nerve signaling, immune response and hormones.
Yoshua Quinones, MD, a board-certified internist with Medical Offices of Manhattan, NY, not involved in this research, explained to Medical News Today:
“The microbiome affects cardiovascular disease risk by producing metabolites like TMAO (trimethylamine N-oxide) and SCFAs (short-chain fatty acids), modulating inflammation and immune responses, influencing lipid and glucose metabolism, regulating blood pressure, and altering cholesterol absorption […] As we age, changes in our immune system, diet, lifestyle, and gut function alter the gut microbiome. This leads to fewer different types of bacteria and changes in how they work, affecting our overall health and risk of diseases.”
First, the researchers looked at a cohort of 10,207 Chinese participants, collecting information on 21 metabolic parameters to classify…
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