- More than 1 billion people worldwide have obesity.
- About 28.5 million people globally have high cholesterol.
- Both conditions increase a person’s risk for other diseases such as cardiovascular disease and diabetes.
- Researchers from the University of Massachusetts Amherst have designed a nanogel-based carrier to deliver a drug that mimics synthetic thyroid hormone directly to the liver.
- Scientists found via a mouse model that this liver-targeted drug system helped obese mice return to a healthy weight and lower their cholesterol levels.
More than
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People who are obese and/or have high cholesterol are at a higher risk for other diseases such as cardiovascular disease, high blood pressure, diabetes, and even certain types of cancer.
Now, researchers from the University of Massachusetts Amherst have designed a
Scientists found via a mouse model this liver-targeted drug system helped obese mice return to a healthy weight and lower their cholesterol levels.
This study was recently published in the journal PNAS NEXUS.
For this study, researchers engineered a nanogel-based carrier to deliver a drug directly to the liver.
Dr. S. Thai Thayumanavan, distinguished professor of chemistry and biomedical engineering, department head of biomedical engineering, director of the Center for Bioactive Delivery at the University of Massachusetts Amherst, and lead author of this study explained to Medical News Today:
“Our
nanogels have an inherent propensity to home in the liver and then there is a specific need for…
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