- Blood sugar control and weight loss can be more effectively achieved with higher doses of oral semaglutide, according to a new study.
- While oral semaglutide is approved for controlling type 2 diabetes, it also shows promise as a weight-loss drug for people with obesity.
- The study confirms that once-daily oral doses of semaglutide may be capable of replacing current injectable semaglutide medications.
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A new study of semaglutide finds its effect on blood sugar and appetite is dose-dependent, with higher doses proving more effective than current prescription levels.
Semaglutide medications are approved for the treatment of type 2 diabetes as an accompaniment to diet and exercise, typically as once-weekly injections or once-daily oral drugs.
For many people with type 2 diabetes and their physicians, oral medications are preferred due to their greater convenience, including not having to get a shot.
Currently, oral semaglutide is prescribed in 3 mg, 7 mg, and 14 mg formulations. The new study tests the effectiveness of 14 mg doses against 25 mg and 50 mg formulations.
The study describes a randomized, double-blind,
Divided randomly into three groups, participants took oral semaglutide once daily for 68 weeks. One group took a 14 mg formulation, another group took 25 mg, and the third group took 50 mg.
The researchers measured individuals’ HbA1C — which reflects average blood sugar levels over the past three months — at the outset of the study and…
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