- New research sheds light on the genetic basis of the link between migraine and certain blood sugar-related traits, such as fasting insulin and glycated hemoglobin.
- The co-occurrence of headache, migraine, and blood sugar imbalance has been previously reported and there are shared links between migraine, headache, and blood sugar regulation. Additionally, several genes have been identified as risk factors for migraine.
- Now, researchers have identified a potential causal relationship that may pave the way for the development of new prevention and treatment options.
A new study, published in the journal Human Genetics, analyzed data from hundreds of thousands of human genomes from individuals with and without a history of migraine or headache.
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However, it was unclear how these conditions were genetically linked.
To investigate this relationship, researchers analyzed large-scale genetic data from European populations.
They looked for genetic similarities between migraine, headache, and nine blood sugar-related traits. They also identified regions of the genome that were linked to both types of conditions.
The researchers also suggested a potential causal relationship between increased fasting proinsulin levels and decreased risk of headaches.
The researchers conducted a meta-analysis with blood sugar-related traits that they say identified six new genetic markers associated with migraine and headache, finding that certain genes were associated with these conditions.
They said these findings provide insights into the biological mechanisms underlying the comorbidity of these conditions.
Using a statistical technique called
They reported some evidence to suggest that…
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