- Coronary artery disease is characterized by a dysfunction of the endothelial cells that form the innermost lining of all blood vessels.
- A new study has identified five biological pathways regulated by a few genes that could potentially play a prominent role in coronary artery disease through their involvement in endothelial cell function.
- Notably, these pathways included genes whose role in coronary artery disease has not been previously demonstrated.
- One of the genes in these pathways, TLNRD1, plays an essential role in endothelial function, cardiovascular health, and potentially coronary artery disease, according to the study.
- These findings could lead to the development of novel therapies targeting endothelial cell dysfunction in coronary artery disease.
Coronary artery disease is the
These effects of statins are mediated, in part, by improving blood vessel health. However, there is a lack of therapies for coronary artery disease that directly target the
Identifying genetic risk factors associated with endothelial cell function could help develop therapeutics that target blood vessels.
Research has shown that specific
However, methodological limitations have impeded the identification of major pathways associated with coronary artery disease variants.
A new study using a combination of high-throughput molecular biology techniques and computational methods has identified major biological pathways and novel genes involved in endothelial cell function that could contribute to the risk of coronary artery…
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