Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes, but underlying mechanisms are not well understood. In new research, scientists from the Erasmus MC University Medical Center Rotterdam and elsewhere studied the role of classic and novel-diabetes biomarkers with anti- or pro-inflammatory activity in the association between habitual coffee intake and type 2 diabetes risk.
Coffee is one of the most frequently consumed beverages worldwide. It contains several bioactive compounds such as chlorogenic acids, caffeine and polyphenols, although the exact composition depends on the type and preparation process.
The beneficial association between higher coffee consumption and lower risk of type 2 diabetes mellitus is well-established. However, potential mechanisms underlying these associations are not well understood.
Diabetes is related to inflammation and a large number of studies have reported altered concentrations of classic subclinical inflammation markers, such as C-reactive protein; adipokines, such as leptin and adiponectin; and novel biomarkers of inflammation such as complement proteins, interleukins (IL-13 and IL-17), and receptors, in insulin resistant and diabetic patients.
Higher coffee intake has been suggested to lead to lower concentrations of pro-inflammatory markers, which may thereby impact the risk of type 2 diabetes and other cardiometabolic diseases
“To help understand biological pathways connecting coffee to inflammatory processes and type 2 diabetes development, we aimed:” said Dr. Trudy Voortman from the Erasmus MC University Medical Center Rotterdam and colleagues.
“Firstly, to determine longitudinal associations of long-term habitual coffee consumption with insulin resistance and type 2 diabetes.”
“Secondly, to investigate to what extent classic and novel type 2 diabetes-related markers of inflammation and adipokines mediate these associations through…
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