It’s long been known that mice can be trained to perform simple tasks in exchange for a reward. Bribe a hungry mouse with a morsel of food or a thirsty mouse with a drop of water and you can encourage it to navigate a maze or click a particular button. But sometimes, mice don’t act as expected, failing to complete the task at hand. Often, researchers have dismissed these actions as simple mistakes, resulting from inattention or disengagement. Yet, a study published April 26 in the journal Current Biology suggests, there’s more going on: mice can understand the rules of a task and still deviate in their behaviors, potentially testing their own hypotheses and attempting to learn more about their surroundings.
It appears that the decisions mice make during behavioral tests are more complicated than just basic reward-seeking choices. During human-imposed trials in the lab, mice may be continually exploring and re-testing the rules of their environment and performing their own small experiments.
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The findings expand our understanding of what’s happening inside rodent brains and indicate mice and other non-verbal animals might know more than they let on. The research could eventually help shed light on the neurological underpinnings of human behavior as well. “These mice have a richer internal life than we probably give them credit for,” says Kishore Kuchibhotla, senior study author and an assistant professor of neuroscience at Johns Hopkins University. “They are not just stimulus response machines. They may have things like strategies,” he adds.
Mice at the steering wheel
The work builds on previous research that tested mice on a simple licking task and adds a level of complexity with a…
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