In recent years, exploring natural compounds with functional properties to ameliorate aging-associated cognitive decline has become a research priority to ensure healthy aging. In a new study, researchers at the University of Tsukuba investigated the effects of trigonelline — a naturally occurring alkaloid compound found in various plants, including coffee beans, fenugreek, and Japanese radish — on memory and spatial learning in a mouse model of accelerated aging.
Cognitive aging refers to age-related impairments in cognitive functions, including slower problem-solving, reduced fluid reasoning, diminished perceptual speed, and impaired memory and spatial ability.
It stands as one of the most common health concerns among older individuals.
It is estimated that cognitive impairment affects over 11.7% of adults aged 65 and above, with the prevalence increasing to approximately 40% among those aged 80 and older.
According to the WHO, neurodegenerative disorders will rank second among all causes of natural mortality by 2040.
The rise in life expectancy worldwide, particularly in advanced nations, contributes to a substantial increase in the global incidence of cognitive impairment.
Cognitive aging significantly impacts the quality of life for older adults, places strain on healthcare providers and systems and imposes substantial economic burdens on families and society as a whole.
Therefore, it is imperative to take proactive measures to support brain health among older adults and foster healthy aging on a broader scale.
“Trigonelline has been extensively studied for its numerous biological activities, including antimicrobial, anticancer, antidiabetic, antihypertensive, and anti-hyperlipidemic effects,” said University of Tsukuba’s Professor Hiroko Isoda and colleagues.
“Notably, previous studies also reported that trigonelline promotes the regeneration of dendrites and axons in cortical neurons and inhibits the formation of advanced glycation end…
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