The human Y chromosome, responsible for determining male sex, finally has gotten an end-to-end examination.
Researchers sequenced the chromosome, which contains many genes involved in sperm production and fertility, from a male of European descent. The new telomere-to-telomere, or tip-to-tip, construction adds more than 30 million DNA bases to a previously assembled reference Y chromosome, the team reports online August 23 in Nature. It is the final piece of the human pangenome, an effort to catalog all human DNA (SN: 5/10/23).
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